Jeffrey A Winkles Selected Research

Fibroblast Growth Factors (Fibroblast Growth Factor)

1/2021	Elevated fibroblast growth factor-inducible 14 expression transforms proneural-like gliomas into more aggressive and lethal brain cancer.
1/2020	Decreased nonspecific adhesivity, receptor-targeted therapeutic nanoparticles for primary and metastatic breast cancer.
1/2018	EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival.
2/2017	Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells.
1/2014	Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
4/2013	The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment.
4/2013	The HER2- and heregulin β1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression.
7/2012	Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion.
7/2012	Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
7/2011	Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells.

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Jeffrey A Winkles Research Topics

Disease

32	Neoplasms (Cancer) 09/2022 - 04/2003
16	Glioma (Gliomas) 01/2021 - 04/2003
11	Glioblastoma (Glioblastoma Multiforme) 06/2018 - 04/2003
9	Brain Neoplasms (Brain Tumor) 12/2021 - 02/2005
7	Breast Neoplasms (Breast Cancer) 12/2021 - 05/2008
5	Necrosis 01/2021 - 04/2003
3	Inflammation (Inflammations) 07/2011 - 04/2008
3	Ankylosis 08/2010 - 07/2003
2	Sarcoma (Soft Tissue Sarcoma) 01/2021 - 01/2017
2	Wounds and Injuries (Trauma) 12/2013 - 01/2013
2	Melanoma (Melanoma, Malignant) 07/2013 - 04/2013
2	Neoplasm Metastasis (Metastasis) 04/2013 - 05/2008
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/2007 - 02/2005
2	Stroke (Strokes) 01/2007 - 02/2005
2	Rheumatoid Arthritis 01/2007 - 12/2004
2	Pathologic Neovascularization 12/2004 - 04/2003
1	Triple Negative Breast Neoplasms 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2018
1	Gliosarcoma 01/2018
1	Central Nervous System Diseases (CNS Diseases) 01/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2013
1	Urinary Bladder Neoplasms (Bladder Cancer) 07/2011

Drug/Important Bio-Agent (IBA)

15	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2003
14	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 01/2021 - 02/2005
11	TWEAK ReceptorIBA 01/2021 - 04/2003
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2017 - 12/2004
8	CytokinesIBA 12/2013 - 12/2004
6	Pharmaceutical PreparationsIBA 01/2019 - 07/2012
6	NF-kappa B (NF-kB)IBA 11/2009 - 04/2003
5	Biological ProductsIBA 01/2021 - 02/2005
5	Messenger RNA (mRNA)IBA 06/2018 - 04/2003
5	Small Interfering RNA (siRNA)IBA 01/2017 - 02/2005
4	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 06/2018 - 10/2006
4	Cytokine TWEAKIBA 11/2014 - 02/2005
3	Cell Surface ReceptorsIBA 01/2020 - 04/2003
3	Temozolomide (Temodar)FDA LinkGeneric 01/2018 - 02/2017
3	LigandsIBA 07/2011 - 01/2007
2	Virus ReceptorsIBA 01/2021 - 01/2017
2	Albumin-Bound Paclitaxel FDA Link 01/2020 - 01/2016
2	Immunoconjugates (Immunoconjugate)IBA 01/2020 - 07/2011
2	EnzymesIBA 12/2018 - 06/2018
2	Phosphotransferases (Kinase)IBA 01/2014 - 06/2008
2	Immunotoxins (Immunotoxin)IBA 07/2013 - 04/2013
2	diphosphoric acid (pyrophosphoric acid)IBA 08/2010 - 01/2009
1	Immunomodulating AgentsIBA 12/2021
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Plasminogen Activator Inhibitor 1IBA 01/2021
1	Complement System Proteins (Complement)IBA 01/2021
1	gamma-glutamylaminomethylsulfonic acid (GAMS)IBA 01/2021
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2020
1	Surface-Active Agents (Surfactants)IBA 01/2019
1	Hydroxyl RadicalIBA 01/2019
1	Polylactic Acid-Polyglycolic Acid CopolymerIBA 01/2019
1	Dendrimers (Dendrons)IBA 01/2019
1	Liposomes (Liposome)IBA 01/2019
1	UCON 50-HB-5100 (F127)IBA 01/2019
1	AminesIBA 01/2019
1	Cholic AcidIBA 01/2019
1	ArginaseIBA 12/2018
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2018
1	Conditioned Culture MediaIBA 12/2018
1	MethyltransferasesIBA 12/2018
1	Decitabine FDA Link 06/2018
1	AGI-5198IBA 06/2018
1	DNA (Deoxyribonucleic Acid)IBA 06/2018
1	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 06/2018
1	Platelet-Derived Growth FactorIBA 01/2018
1	epidermal growth factor receptor VIIIIBA 01/2018
1	DNA Transposable Elements (Element, IS)IBA 12/2017
1	Aurintricarboxylic AcidIBA 02/2017
1	Transcription Factors (Transcription Factor)IBA 02/2017
1	NestinIBA 01/2017
1	GlycosaminoglycansIBA 01/2017
1	PlatinumIBA 01/2016
1	Drug CarriersIBA 01/2016
1	matrigelIBA 01/2016
1	Ethylene Glycol (Monoethylene Glycol)IBA 01/2016
1	N- phenylacetoaminomethylene- DL- p- nitrophenylalanine (A 101)IBA 11/2014
1	Hormones (Hormone)IBA 11/2014
1	GuanosineIBA 01/2014
1	Chemotactic FactorsIBA 01/2014
1	Trastuzumab (Herceptin)FDA Link 07/2013
1	histidine-rich proteinsIBA 04/2013
1	Neuregulin-1 (Neuregulin 1)IBA 04/2013
1	Indicators and Reagents (Reagents)IBA 04/2013
1	Ephrin-A3 (Ephrin A3)IBA 02/2013
1	ErbB Receptors (EGF Receptor)IBA 07/2012
1	GTP Phosphohydrolases (GTPases)IBA 07/2012
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 07/2012
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 07/2012
1	Serine (L-Serine)FDA Link 11/2009
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 11/2009

Therapy/Procedure

18	Therapeutics 09/2022 - 02/2005
4	Drug Therapy (Chemotherapy) 01/2021 - 11/2009
2	Radiotherapy 01/2018 - 11/2009
1	Lasers (Laser) 01/2022
1	Optical Fibers 01/2022
1	Immunotherapy 12/2021
1	Ultrasonic Therapy 11/2016